Enoxaparin versus unfractionated heparin in elective percutaneous coronary intervention
Identifieur interne : 009F71 ( Main/Exploration ); précédent : 009F70; suivant : 009F72Enoxaparin versus unfractionated heparin in elective percutaneous coronary intervention
Auteurs : Gilles Montalescot [France] ; Harvey D. White [Nouvelle-Zélande] ; Richard Gallo [Canada] ; Marc Cohen [États-Unis] ; P. Gabriel Steg [France] ; Philip E. G. Aylward [Australie] ; Christoph Bode [Allemagne] ; Massimo Chiariello [Italie] ; Spencer B. Iii King [États-Unis] ; Robert A. Harrington [États-Unis] ; Walter J. Desmet [Belgique] ; Carlos Macaya [Espagne] ; Steven R. Steinhubl [États-Unis]Source :
- The New England journal of medicine [ 0028-4793 ] ; 2006.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Médecine.
English descriptors
- KwdEn :
Abstract
BACKGROUND Despite its limitations, unfractionated heparin has been the standard anticoagulant used during percutaneous coronary intervention (PCI). Several small studies have suggested that intravenous enoxaparin may be a safe and effective alternative. Our primary aim was to assess the safety of enoxaparin as compared with that of unfractionated heparin in elective PCI. METHODS In this prospective, open-label, multicenter, randomized trial, we randomly assigned 3528 patients with PCI to receive enoxaparin (0.5 or 0.75 mg per kilogram of body weight) or unfractionated heparin adjusted for activated clotting time, stratified according to the use or nonuse of glycoprotein IIb/IIIa inhibitors. The primary end point was the incidence of major or minor bleeding that was not related to coronary-artery bypass grafting. The main secondary end point was the percentage of patients in whom the target anticoagulation levels were reached. RESULTS Enoxaparin at a dose of 0.5 mg per kilogram was associated with a significant reduction in the rate of non-CABG-related bleeding in the first 48 hours, as compared with unfractionated heparin (5.9% vs. 8.5%; absolute difference, -2.6; 95% confidence interval [CI], -4.7 to -0.6; P=0.01), but the higher enoxaparin dose was not (6.5% vs. 8.5%; absolute difference, -2.0; 95% CI, -4.0 to 0.0; P=0.051). The incidence of major bleeding was significantly reduced in both enoxaparin groups, as compared with the unfractionated heparin group. Target anticoagulation levels were reached in significantly more patients who received enoxaparin (0.5-mg-per-kilogram dose, 79%; 0.75-mg-per-kilogram dose, 92%) than who received unfractionated heparin (20%, P<0.001). CONCLUSIONS In elective PCI, a single intravenous bolus of 0.5 mg of enoxaparin per kilogram is associated with reduced rates of bleeding, and a dose of 0.75 mg per kilogram yields rates similar to those for unfractionated heparin, with more predictable anticoagulation levels. The trial was not large enough to provide a definitive comparison of efficacy in the prevention of ischemic events.
Affiliations:
- Allemagne, Australie, Belgique, Canada, Espagne, France, Italie, Nouvelle-Zélande, États-Unis
- Bade-Wurtemberg, Communauté de Madrid, District de Fribourg-en-Brisgau, Québec, Île-de-France
- Fribourg-en-Brisgau, Madrid, Montréal, Paris
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 004176
- to stream PascalFrancis, to step Curation: 001F19
- to stream PascalFrancis, to step Checkpoint: 004071
- to stream Main, to step Merge: 00AA93
- to stream Main, to step Curation: 009F71
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Enoxaparin versus unfractionated heparin in elective percutaneous coronary intervention</title><author><name sortKey="Montalescot, Gilles" sort="Montalescot, Gilles" uniqKey="Montalescot G" first="Gilles" last="Montalescot">Gilles Montalescot</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institut de Cardiologie, Centre Hospitalier Universitaire Pitié-Salpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="White, Harvey D" sort="White, Harvey D" uniqKey="White H" first="Harvey D." last="White">Harvey D. White</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Green LaneCardiovascular Service, Auckland City Hospital</s1><s2>Auckland</s2><s3>NZL</s3><sZ>2 aut.</sZ></inist:fA14><country>Nouvelle-Zélande</country><wicri:noRegion>Auckland</wicri:noRegion></affiliation></author><author><name sortKey="Gallo, Richard" sort="Gallo, Richard" uniqKey="Gallo R" first="Richard" last="Gallo">Richard Gallo</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Montreal Heart Institute, Université de Montréal</s1><s2>Montreal</s2><s3>CAN</s3><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Cohen, Marc" sort="Cohen, Marc" uniqKey="Cohen M" first="Marc" last="Cohen">Marc Cohen</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Division of Cardiology, Newark Beth Israel Medical Center</s1><s2>Newark, NJ</s2><s3>USA</s3><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Newark, NJ</wicri:noRegion></affiliation></author><author><name sortKey="Steg, P Gabriel" sort="Steg, P Gabriel" uniqKey="Steg P" first="P. Gabriel" last="Steg">P. Gabriel Steg</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Service de Cardiologie, Hôpital Bichat</s1><s2>Paris</s2><s3>FRA</s3><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Aylward, Philip E G" sort="Aylward, Philip E G" uniqKey="Aylward P" first="Philip E. G." last="Aylward">Philip E. G. Aylward</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Cardiology, Flinders Medical Center</s1><s2>Adelaide, SA</s2><s3>AUS</s3><sZ>6 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Adelaide, SA</wicri:noRegion></affiliation></author><author><name sortKey="Bode, Christoph" sort="Bode, Christoph" uniqKey="Bode C" first="Christoph" last="Bode">Christoph Bode</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Abteilung Innere Medizin III, Universitätsklinikum Freiburg</s1><s2>Freiburg</s2><s3>DEU</s3><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Fribourg-en-Brisgau</region><settlement type="city">Fribourg-en-Brisgau</settlement></placeName></affiliation></author><author><name sortKey="Chiariello, Massimo" sort="Chiariello, Massimo" uniqKey="Chiariello M" first="Massimo" last="Chiariello">Massimo Chiariello</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Division of Cardiology, Federico 2nd University</s1><s2>Naples</s2><s3>ITA</s3><sZ>8 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="King, Spencer B Iii" sort="King, Spencer B Iii" uniqKey="King S" first="Spencer B. Iii" last="King">Spencer B. Iii King</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Fuqua Heart Center of Atlanta at Piedmont Hospital</s1><s2>Atlanta</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Fuqua Heart Center of Atlanta at Piedmont Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Harrington, Robert A" sort="Harrington, Robert A" uniqKey="Harrington R" first="Robert A." last="Harrington">Robert A. Harrington</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Division of Cardiology, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Durham, NC</wicri:noRegion></affiliation></author><author><name sortKey="Desmet, Walter J" sort="Desmet, Walter J" uniqKey="Desmet W" first="Walter J." last="Desmet">Walter J. Desmet</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>University Hospital Gasthuisberg</s1><s2>Leuven</s2><s3>BEL</s3><sZ>11 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>University Hospital Gasthuisberg</wicri:noRegion></affiliation></author><author><name sortKey="Macaya, Carlos" sort="Macaya, Carlos" uniqKey="Macaya C" first="Carlos" last="Macaya">Carlos Macaya</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Servicio de Cardiologfa, Hospital Universitario</s1><s2>Madrid</s2><s3>ESP</s3><sZ>12 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Steinhubl, Steven R" sort="Steinhubl, Steven R" uniqKey="Steinhubl S" first="Steven R." last="Steinhubl">Steven R. Steinhubl</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Division of Cardiology, University of Kentucky</s1><s2>Lexington</s2><s3>USA</s3><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Lexington</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">06-0430654</idno><date when="2006">2006</date><idno type="stanalyst">PASCAL 06-0430654 INIST</idno><idno type="RBID">Pascal:06-0430654</idno><idno type="wicri:Area/PascalFrancis/Corpus">004176</idno><idno type="wicri:Area/PascalFrancis/Curation">001F19</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">004071</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">004071</idno><idno type="wicri:doubleKey">0028-4793:2006:Montalescot G:enoxaparin:versus:unfractionated</idno><idno type="wicri:Area/Main/Merge">00AA93</idno><idno type="wicri:Area/Main/Curation">009F71</idno><idno type="wicri:Area/Main/Exploration">009F71</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Enoxaparin versus unfractionated heparin in elective percutaneous coronary intervention</title><author><name sortKey="Montalescot, Gilles" sort="Montalescot, Gilles" uniqKey="Montalescot G" first="Gilles" last="Montalescot">Gilles Montalescot</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institut de Cardiologie, Centre Hospitalier Universitaire Pitié-Salpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="White, Harvey D" sort="White, Harvey D" uniqKey="White H" first="Harvey D." last="White">Harvey D. White</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Green LaneCardiovascular Service, Auckland City Hospital</s1><s2>Auckland</s2><s3>NZL</s3><sZ>2 aut.</sZ></inist:fA14><country>Nouvelle-Zélande</country><wicri:noRegion>Auckland</wicri:noRegion></affiliation></author><author><name sortKey="Gallo, Richard" sort="Gallo, Richard" uniqKey="Gallo R" first="Richard" last="Gallo">Richard Gallo</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Montreal Heart Institute, Université de Montréal</s1><s2>Montreal</s2><s3>CAN</s3><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Cohen, Marc" sort="Cohen, Marc" uniqKey="Cohen M" first="Marc" last="Cohen">Marc Cohen</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Division of Cardiology, Newark Beth Israel Medical Center</s1><s2>Newark, NJ</s2><s3>USA</s3><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Newark, NJ</wicri:noRegion></affiliation></author><author><name sortKey="Steg, P Gabriel" sort="Steg, P Gabriel" uniqKey="Steg P" first="P. Gabriel" last="Steg">P. Gabriel Steg</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Service de Cardiologie, Hôpital Bichat</s1><s2>Paris</s2><s3>FRA</s3><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Aylward, Philip E G" sort="Aylward, Philip E G" uniqKey="Aylward P" first="Philip E. G." last="Aylward">Philip E. G. Aylward</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Cardiology, Flinders Medical Center</s1><s2>Adelaide, SA</s2><s3>AUS</s3><sZ>6 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Adelaide, SA</wicri:noRegion></affiliation></author><author><name sortKey="Bode, Christoph" sort="Bode, Christoph" uniqKey="Bode C" first="Christoph" last="Bode">Christoph Bode</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Abteilung Innere Medizin III, Universitätsklinikum Freiburg</s1><s2>Freiburg</s2><s3>DEU</s3><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Fribourg-en-Brisgau</region><settlement type="city">Fribourg-en-Brisgau</settlement></placeName></affiliation></author><author><name sortKey="Chiariello, Massimo" sort="Chiariello, Massimo" uniqKey="Chiariello M" first="Massimo" last="Chiariello">Massimo Chiariello</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Division of Cardiology, Federico 2nd University</s1><s2>Naples</s2><s3>ITA</s3><sZ>8 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="King, Spencer B Iii" sort="King, Spencer B Iii" uniqKey="King S" first="Spencer B. Iii" last="King">Spencer B. Iii King</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Fuqua Heart Center of Atlanta at Piedmont Hospital</s1><s2>Atlanta</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Fuqua Heart Center of Atlanta at Piedmont Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Harrington, Robert A" sort="Harrington, Robert A" uniqKey="Harrington R" first="Robert A." last="Harrington">Robert A. Harrington</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Division of Cardiology, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Durham, NC</wicri:noRegion></affiliation></author><author><name sortKey="Desmet, Walter J" sort="Desmet, Walter J" uniqKey="Desmet W" first="Walter J." last="Desmet">Walter J. Desmet</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>University Hospital Gasthuisberg</s1><s2>Leuven</s2><s3>BEL</s3><sZ>11 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>University Hospital Gasthuisberg</wicri:noRegion></affiliation></author><author><name sortKey="Macaya, Carlos" sort="Macaya, Carlos" uniqKey="Macaya C" first="Carlos" last="Macaya">Carlos Macaya</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Servicio de Cardiologfa, Hospital Universitario</s1><s2>Madrid</s2><s3>ESP</s3><sZ>12 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Steinhubl, Steven R" sort="Steinhubl, Steven R" uniqKey="Steinhubl S" first="Steven R." last="Steinhubl">Steven R. Steinhubl</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Division of Cardiology, University of Kentucky</s1><s2>Lexington</s2><s3>USA</s3><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Lexington</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">The New England journal of medicine</title><title level="j" type="abbreviated">N. Engl. j. med.</title><idno type="ISSN">0028-4793</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">The New England journal of medicine</title><title level="j" type="abbreviated">N. Engl. j. med.</title><idno type="ISSN">0028-4793</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Angioplasty</term><term>Anticoagulant</term><term>Comparative study</term><term>Coronary artery</term><term>Coronary heart disease</term><term>Enoxaparin sodium</term><term>Instrumentation therapy</term><term>Low molecular weight heparin</term><term>Medicine</term><term>Stent</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Cardiopathie coronaire</term><term>Enoxaparine sodique</term><term>Héparine bas poids moléculaire</term><term>Etude comparative</term><term>Artère coronaire</term><term>Stent</term><term>Angioplastie</term><term>Médecine</term><term>Anticoagulant</term><term>Traitement instrumental</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Médecine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">BACKGROUND Despite its limitations, unfractionated heparin has been the standard anticoagulant used during percutaneous coronary intervention (PCI). Several small studies have suggested that intravenous enoxaparin may be a safe and effective alternative. Our primary aim was to assess the safety of enoxaparin as compared with that of unfractionated heparin in elective PCI. METHODS In this prospective, open-label, multicenter, randomized trial, we randomly assigned 3528 patients with PCI to receive enoxaparin (0.5 or 0.75 mg per kilogram of body weight) or unfractionated heparin adjusted for activated clotting time, stratified according to the use or nonuse of glycoprotein IIb/IIIa inhibitors. The primary end point was the incidence of major or minor bleeding that was not related to coronary-artery bypass grafting. The main secondary end point was the percentage of patients in whom the target anticoagulation levels were reached. RESULTS Enoxaparin at a dose of 0.5 mg per kilogram was associated with a significant reduction in the rate of non-CABG-related bleeding in the first 48 hours, as compared with unfractionated heparin (5.9% vs. 8.5%; absolute difference, -2.6; 95% confidence interval [CI], -4.7 to -0.6; P=0.01), but the higher enoxaparin dose was not (6.5% vs. 8.5%; absolute difference, -2.0; 95% CI, -4.0 to 0.0; P=0.051). The incidence of major bleeding was significantly reduced in both enoxaparin groups, as compared with the unfractionated heparin group. Target anticoagulation levels were reached in significantly more patients who received enoxaparin (0.5-mg-per-kilogram dose, 79%; 0.75-mg-per-kilogram dose, 92%) than who received unfractionated heparin (20%, P<0.001). CONCLUSIONS In elective PCI, a single intravenous bolus of 0.5 mg of enoxaparin per kilogram is associated with reduced rates of bleeding, and a dose of 0.75 mg per kilogram yields rates similar to those for unfractionated heparin, with more predictable anticoagulation levels. The trial was not large enough to provide a definitive comparison of efficacy in the prevention of ischemic events.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Canada</li><li>Espagne</li><li>France</li><li>Italie</li><li>Nouvelle-Zélande</li><li>États-Unis</li></country><region><li>Bade-Wurtemberg</li><li>Communauté de Madrid</li><li>District de Fribourg-en-Brisgau</li><li>Québec</li><li>Île-de-France</li></region><settlement><li>Fribourg-en-Brisgau</li><li>Madrid</li><li>Montréal</li><li>Paris</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Montalescot, Gilles" sort="Montalescot, Gilles" uniqKey="Montalescot G" first="Gilles" last="Montalescot">Gilles Montalescot</name></region><name sortKey="Steg, P Gabriel" sort="Steg, P Gabriel" uniqKey="Steg P" first="P. Gabriel" last="Steg">P. Gabriel Steg</name></country><country name="Nouvelle-Zélande"><noRegion><name sortKey="White, Harvey D" sort="White, Harvey D" uniqKey="White H" first="Harvey D." last="White">Harvey D. White</name></noRegion></country><country name="Canada"><region name="Québec"><name sortKey="Gallo, Richard" sort="Gallo, Richard" uniqKey="Gallo R" first="Richard" last="Gallo">Richard Gallo</name></region></country><country name="États-Unis"><noRegion><name sortKey="Cohen, Marc" sort="Cohen, Marc" uniqKey="Cohen M" first="Marc" last="Cohen">Marc Cohen</name></noRegion><name sortKey="Harrington, Robert A" sort="Harrington, Robert A" uniqKey="Harrington R" first="Robert A." last="Harrington">Robert A. Harrington</name><name sortKey="King, Spencer B Iii" sort="King, Spencer B Iii" uniqKey="King S" first="Spencer B. Iii" last="King">Spencer B. Iii King</name><name sortKey="Steinhubl, Steven R" sort="Steinhubl, Steven R" uniqKey="Steinhubl S" first="Steven R." last="Steinhubl">Steven R. Steinhubl</name></country><country name="Australie"><noRegion><name sortKey="Aylward, Philip E G" sort="Aylward, Philip E G" uniqKey="Aylward P" first="Philip E. G." last="Aylward">Philip E. G. Aylward</name></noRegion></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Bode, Christoph" sort="Bode, Christoph" uniqKey="Bode C" first="Christoph" last="Bode">Christoph Bode</name></region></country><country name="Italie"><noRegion><name sortKey="Chiariello, Massimo" sort="Chiariello, Massimo" uniqKey="Chiariello M" first="Massimo" last="Chiariello">Massimo Chiariello</name></noRegion></country><country name="Belgique"><noRegion><name sortKey="Desmet, Walter J" sort="Desmet, Walter J" uniqKey="Desmet W" first="Walter J." last="Desmet">Walter J. Desmet</name></noRegion></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Macaya, Carlos" sort="Macaya, Carlos" uniqKey="Macaya C" first="Carlos" last="Macaya">Carlos Macaya</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 009F71 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 009F71 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:06-0430654
|texte= Enoxaparin versus unfractionated heparin in elective percutaneous coronary intervention
}}
| This area was generated with Dilib version V0.6.33. |  |